ID   CQ080_HUMAN             Reviewed;         609 AA.
AC   Q9BSJ5; A8K9X3; Q5JB45; Q6YAU3; Q9H0L9; Q9H5E6; Q9NWN5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   14-DEC-2022, entry version 134.
DE   RecName: Full=Uncharacterized protein C17orf80;
DE   AltName: Full=Cell migration-inducing gene 3 protein;
DE   AltName: Full=Human lung cancer oncogene 8 protein;
DE            Short=HLC-8;
GN   Name=C17orf80; ORFNames=HLC8, MIG3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 377-609 (ISOFORM 1), AND VARIANTS LEU-356; ASN-395;
RP   ARG-396; HIS-420 AND THR-522.
RA   Kim J.W.;
RT   "Identification of a new human cancer-related gene (HLC-8).";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ASN-395.
RC   TISSUE=Testis;
RX   PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA   Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA   Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA   Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and analysis of
RT   500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANTS
RP   ASN-395; HIS-420 AND THR-522.
RC   TISSUE=Lung, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-395.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASN-395.
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9BSJ5; P21333-2: FLNA; NbExp=3; IntAct=EBI-2872520, EBI-9641086;
CC       Q9BSJ5; Q9HB07: MYG1; NbExp=3; IntAct=EBI-2872520, EBI-709754;
CC       Q9BSJ5; Q8N2W9: PIAS4; NbExp=3; IntAct=EBI-2872520, EBI-473160;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9BSJ5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BSJ5-2; Sequence=VSP_024572;
CC       Name=3;
CC         IsoId=Q9BSJ5-3; Sequence=VSP_024573, VSP_024574;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP72185.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAA91344.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAB15680.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY163812; AAO25513.1; -; mRNA.
DR   EMBL; AY239293; AAP72185.1; ALT_INIT; mRNA.
DR   EMBL; AL136740; CAB66674.1; -; mRNA.
DR   EMBL; AK000728; BAA91344.1; ALT_FRAME; mRNA.
DR   EMBL; AK027166; BAB15680.1; ALT_INIT; mRNA.
DR   EMBL; AK292838; BAF85527.1; -; mRNA.
DR   EMBL; AC087301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC097641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471099; EAW89118.1; -; Genomic_DNA.
DR   EMBL; BC005005; AAH05005.1; -; mRNA.
DR   CCDS; CCDS11694.1; -. [Q9BSJ5-1]
DR   CCDS; CCDS42377.1; -. [Q9BSJ5-2]
DR   CCDS; CCDS45767.1; -. [Q9BSJ5-3]
DR   RefSeq; NP_001094091.1; NM_001100621.2. [Q9BSJ5-2]
DR   RefSeq; NP_001275699.1; NM_001288770.1. [Q9BSJ5-2]
DR   RefSeq; NP_060411.2; NM_017941.5. [Q9BSJ5-1]
DR   RefSeq; XP_005257544.1; XM_005257487.3.
DR   RefSeq; XP_011523263.1; XM_011524961.1. [Q9BSJ5-1]
DR   RefSeq; XP_011523264.1; XM_011524962.2. [Q9BSJ5-1]
DR   RefSeq; XP_016880295.1; XM_017024806.1.
DR   AlphaFoldDB; Q9BSJ5; -.
DR   BioGRID; 120358; 262.
DR   IntAct; Q9BSJ5; 35.
DR   MINT; Q9BSJ5; -.
DR   STRING; 9606.ENSP00000351937; -.
DR   iPTMnet; Q9BSJ5; -.
DR   MetOSite; Q9BSJ5; -.
DR   PhosphoSitePlus; Q9BSJ5; -.
DR   SwissPalm; Q9BSJ5; -.
DR   BioMuta; C17orf80; -.
DR   DMDM; 317373351; -.
DR   EPD; Q9BSJ5; -.
DR   jPOST; Q9BSJ5; -.
DR   MassIVE; Q9BSJ5; -.
DR   MaxQB; Q9BSJ5; -.
DR   PaxDb; Q9BSJ5; -.
DR   PeptideAtlas; Q9BSJ5; -.
DR   ProteomicsDB; 78901; -. [Q9BSJ5-1]
DR   ProteomicsDB; 78902; -. [Q9BSJ5-2]
DR   ProteomicsDB; 78903; -. [Q9BSJ5-3]
DR   Antibodypedia; 2478; 79 antibodies from 18 providers.
DR   DNASU; 55028; -.
DR   Ensembl; ENST00000268942.12; ENSP00000268942.8; ENSG00000141219.16. [Q9BSJ5-2]
DR   Ensembl; ENST00000359042.6; ENSP00000351937.2; ENSG00000141219.16. [Q9BSJ5-1]
DR   Ensembl; ENST00000426147.6; ENSP00000396970.2; ENSG00000141219.16. [Q9BSJ5-3]
DR   Ensembl; ENST00000535032.7; ENSP00000440551.2; ENSG00000141219.16. [Q9BSJ5-1]
DR   Ensembl; ENST00000577615.5; ENSP00000464132.1; ENSG00000141219.16. [Q9BSJ5-2]
DR   GeneID; 55028; -.
DR   KEGG; hsa:55028; -.
DR   MANE-Select; ENST00000535032.7; ENSP00000440551.2; NM_001351264.2; NP_001338193.2.
DR   UCSC; uc002jjk.3; human. [Q9BSJ5-1]
DR   CTD; 55028; -.
DR   DisGeNET; 55028; -.
DR   GeneCards; C17orf80; -.
DR   HGNC; HGNC:29601; C17orf80.
DR   HPA; ENSG00000141219; Low tissue specificity.
DR   neXtProt; NX_Q9BSJ5; -.
DR   OpenTargets; ENSG00000141219; -.
DR   PharmGKB; PA143485404; -.
DR   VEuPathDB; HostDB:ENSG00000141219; -.
DR   eggNOG; KOG4092; Eukaryota.
DR   GeneTree; ENSGT00510000049019; -.
DR   HOGENOM; CLU_037702_0_0_1; -.
DR   InParanoid; Q9BSJ5; -.
DR   OMA; LYPNYQR; -.
DR   OrthoDB; 1133806at2759; -.
DR   PhylomeDB; Q9BSJ5; -.
DR   TreeFam; TF324369; -.
DR   PathwayCommons; Q9BSJ5; -.
DR   SignaLink; Q9BSJ5; -.
DR   BioGRID-ORCS; 55028; 20 hits in 1064 CRISPR screens.
DR   ChiTaRS; C17orf80; human.
DR   GenomeRNAi; 55028; -.
DR   Pharos; Q9BSJ5; Tbio.
DR   PRO; PR:Q9BSJ5; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9BSJ5; protein.
DR   Bgee; ENSG00000141219; Expressed in sperm and 171 other tissues.
DR   ExpressionAtlas; Q9BSJ5; baseline and differential.
DR   Genevisible; Q9BSJ5; HS.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037694; C17orf80.
DR   PANTHER; PTHR16270; HYPOTHETICAL LOC287798; 1.
DR   AGR; HGNC:29601; -.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..609
FT                   /note="Uncharacterized protein C17orf80"
FT                   /id="PRO_0000284612"
FT   TOPO_DOM        1..552
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        553..573
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        574..609
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          142..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          410..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..441
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         505..540
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11230166,
FT                   ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT                   /id="VSP_024572"
FT   VAR_SEQ         578..583
FT                   /note="KLCRPL -> LQRWRK (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_024573"
FT   VAR_SEQ         584..609
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_024574"
FT   VARIANT         226
FT                   /note="G -> S (in dbSNP:rs9902726)"
FT                   /id="VAR_031779"
FT   VARIANT         322
FT                   /note="K -> Q (in dbSNP:rs34784472)"
FT                   /id="VAR_031780"
FT   VARIANT         356
FT                   /note="F -> L (in dbSNP:rs745143)"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="VAR_031781"
FT   VARIANT         395
FT                   /note="H -> N (in dbSNP:rs904384)"
FT                   /evidence="ECO:0000269|PubMed:11230166,
FT                   ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|Ref.1, ECO:0000269|Ref.5"
FT                   /id="VAR_031782"
FT   VARIANT         396
FT                   /note="C -> R (in dbSNP:rs904383)"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="VAR_031783"
FT   VARIANT         420
FT                   /note="Q -> H (in dbSNP:rs745142)"
FT                   /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.1"
FT                   /id="VAR_031784"
FT   VARIANT         522
FT                   /note="A -> T (in dbSNP:rs1566286)"
FT                   /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.1"
FT                   /id="VAR_031785"
FT   CONFLICT        33
FT                   /note="P -> S (in Ref. 2; CAB66674)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        484
FT                   /note="C -> R (in Ref. 4; BAB15680)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        536
FT                   /note="G -> R (in Ref. 4; BAA91344)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   609 AA;  67315 MW;  2579A2A739C10A43 CRC64;
     MSDNPPRMEV CPYCKKPFKR LKSHLPYCKM IGPTIPTDQK VYQSKPATLP RAKKMKGPIK
     DLIKAKGKEL ETENEERNSK LVVDKPEQTV KTFPLPAVGL ERAATTKADK DIKNPIQPSF
     KMLKNTKPMT TFQEETKAQF YASEKTSPKR ELAKDLPKSG ESRCNPSEAG ASLLVGSIEP
     SLSNQDRKYS STLPNDVQTT SGDLKLDKID PQRQELLVKL LDVPTGDCHI SPKNVSDGVK
     RVRTLLSNER DSKGRDHLSG VPTDVTVTET PEKNTESLIL SLKMSSLGKI QVMEKQEKGL
     TLGVETCGSK GNAEKSMSAT EKQERTVMSH GCENFNTRDS VTGKESQGER PHLSLFIPRE
     TTYQFHSVSQ SSSQSLASLA TTFLQEKKAE AQNHHCVPDV KALMESPEGQ LSLEPKSDSQ
     FQASHTGCQS PLCSAQRHTP QSPFTNHAAA AGRKTLRSCM GLEWFPELYP GYLGLGVLPG
     KPQCWNAMTQ KPQLISPQGE RLSQVSLLER SSTHIRSLEP PAGLTTSNFS LMRLLGAVQK
     GWIRCNTTIR KSGFGGITML FTGYFVLCCS WSFRRLKKLC RPLPWKSTVP PCIGVAKTTG
     DCRSKTCLD
//