ID   KKLC1_HUMAN             Reviewed;         113 AA.
AC   Q5H943;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   02-OCT-2024, entry version 125.
DE   RecName: Full=Kita-kyushu lung cancer antigen 1;
DE            Short=KK-LC-1;
DE   AltName: Full=Cancer/testis antigen 83;
GN   Name=CT83; Synonyms=CXorf61, KKLC1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TOPOLOGY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND IDENTIFICATION AS A
RP   CANCER/TESTIS ANTIGEN.
RX   PubMed=16651449; DOI=10.1158/0008-5472.can-05-3840;
RA   Fukuyama T., Hanagiri T., Takenoyama M., Ichiki Y., Mizukami M., So T.,
RA   Sugaya M., So T., Sugio K., Yasumoto K.;
RT   "Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen
RT   recognized by autologous CTL induced on human lung adenocarcinoma.";
RL   Cancer Res. 66:4922-4928(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16651449};
CC       Single-pass type II membrane protein {ECO:0000269|PubMed:16651449}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testis. Expressed by
CC       cancer cell lines. {ECO:0000269|PubMed:16651449}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z96810; CAI42798.1; -; Genomic_DNA.
DR   EMBL; BC062223; AAH62223.1; -; mRNA.
DR   CCDS; CCDS35372.1; -.
DR   RefSeq; NP_001017978.1; NM_001017978.3.
DR   AlphaFoldDB; Q5H943; -.
DR   SMR; Q5H943; -.
DR   STRING; 9606.ENSP00000360961; -.
DR   ChEMBL; CHEMBL5169155; -.
DR   GlyCosmos; Q5H943; 1 site, No reported glycans.
DR   GlyGen; Q5H943; 1 site.
DR   iPTMnet; Q5H943; -.
DR   PhosphoSitePlus; Q5H943; -.
DR   BioMuta; CT83; -.
DR   jPOST; Q5H943; -.
DR   MassIVE; Q5H943; -.
DR   PaxDb; 9606-ENSP00000360961; -.
DR   PeptideAtlas; Q5H943; -.
DR   ProteomicsDB; 62868; -.
DR   Pumba; Q5H943; -.
DR   Antibodypedia; 591; 68 antibodies from 19 providers.
DR   DNASU; 203413; -.
DR   Ensembl; ENST00000371894.5; ENSP00000360961.4; ENSG00000204019.5.
DR   GeneID; 203413; -.
DR   KEGG; hsa:203413; -.
DR   MANE-Select; ENST00000371894.5; ENSP00000360961.4; NM_001017978.4; NP_001017978.1.
DR   UCSC; uc004eqj.3; human.
DR   AGR; HGNC:33494; -.
DR   CTD; 203413; -.
DR   DisGeNET; 203413; -.
DR   GeneCards; CT83; -.
DR   HGNC; HGNC:33494; CT83.
DR   HPA; ENSG00000204019; Tissue enriched (testis).
DR   MIM; 300625; gene.
DR   neXtProt; NX_Q5H943; -.
DR   OpenTargets; ENSG00000204019; -.
DR   PharmGKB; PA162383081; -.
DR   VEuPathDB; HostDB:ENSG00000204019; -.
DR   eggNOG; ENOG502TE5A; Eukaryota.
DR   GeneTree; ENSGT00390000018873; -.
DR   HOGENOM; CLU_168652_0_0_1; -.
DR   InParanoid; Q5H943; -.
DR   OMA; MEHFLIT; -.
DR   OrthoDB; 4637915at2759; -.
DR   PhylomeDB; Q5H943; -.
DR   SignaLink; Q5H943; -.
DR   BioGRID-ORCS; 203413; 28 hits in 749 CRISPR screens.
DR   GenomeRNAi; 203413; -.
DR   Pharos; Q5H943; Tbio.
DR   PRO; PR:Q5H943; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q5H943; protein.
DR   Bgee; ENSG00000204019; Expressed in sperm and 79 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027940; KKLCAg1.
DR   PANTHER; PTHR38650; KITA-KYUSHU LUNG CANCER ANTIGEN 1; 1.
DR   PANTHER; PTHR38650:SF1; KITA-KYUSHU LUNG CANCER ANTIGEN 1; 1.
DR   Pfam; PF15204; KKLCAg1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Membrane; Proteomics identification;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..113
FT                   /note="Kita-kyushu lung cancer antigen 1"
FT                   /id="PRO_0000293736"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..21
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   113 AA;  12784 MW;  7BC40E0AFFAC587A CRC64;
     MNFYLLLASS ILCALIVFWK YRRFQRNTGE MSSNSTALAL VRPSSSGLIN SNTDNNLAVY
     DLSRDILNNF PHSIARQKRI LVNLSMVENK LVELEHTLLS KGFRGASPHR KST
//