ID   LRP1B_HUMAN             Reviewed;        4599 AA.
AC   Q9NZR2; Q8WY29; Q8WY30; Q8WY31;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   27-MAR-2024, entry version 186.
DE   RecName: Full=Low-density lipoprotein receptor-related protein 1B;
DE            Short=LRP-1B;
DE   AltName: Full=Low-density lipoprotein receptor-related protein-deleted in tumor;
DE            Short=LRP-DIT;
DE   Flags: Precursor;
GN   Name=LRP1B; Synonyms=LRPDIT;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT CYS-3157.
RC   TISSUE=Lung cancer;
RX   PubMed=10766186;
RA   Liu C.-X., Musco S., Lisitsina N.M., Forgacs E., Minna J.D., Lisitsyn N.A.;
RT   "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in
RT   non-small cell lung cancer cell lines.";
RL   Cancer Res. 60:1961-1967(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-2655 AND 2677-4213.
RX   PubMed=11031110; DOI=10.1006/geno.2000.6331;
RA   Liu C.-X., Musco S., Lisitsina N.M., Yaklichkin S.Y., Lisitsyn N.A.;
RT   "Genomic organization of a new candidate tumor suppressor gene, LRP1B.";
RL   Genomics 69:271-274(2000).
RN   [3]
RP   INTERACTION WITH LRPAP1; PLAU; PLAT AND SERPINE1, AND TISSUE SPECIFICITY.
RX   PubMed=11384978; DOI=10.1074/jbc.m102727200;
RA   Liu C.-X., Li Y., Obermoeller-McCormick L.M., Schwartz A.L., Bu G.;
RT   "The putative tumor suppressor LRP1B, a novel member of the low density
RT   lipoprotein (LDL) receptor family, exhibits both overlapping and distinct
RT   properties with the LDL receptor-related protein.";
RL   J. Biol. Chem. 276:28889-28896(2001).
CC   -!- FUNCTION: Potential cell surface proteins that bind and internalize
CC       ligands in the process of receptor-mediated endocytosis.
CC   -!- SUBUNIT: Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by
CC       internalization and degradation of the ligands.
CC   -!- INTERACTION:
CC       Q9NZR2; P05067: APP; NbExp=3; IntAct=EBI-1642131, EBI-77613;
CC       Q9NZR2; P43681: CHRNA4; NbExp=3; IntAct=EBI-1642131, EBI-7132379;
CC       Q9NZR2; P63151: PPP2R2A; NbExp=3; IntAct=EBI-1642131, EBI-1048931;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in thyroid gland and in salivary gland,
CC       as well as in adult and fetal brain. {ECO:0000269|PubMed:11384978}.
CC   -!- MISCELLANEOUS: The gene is preferentially inactivated in one
CC       histological type of lung cancer (non-small cell lung cancer (NSCLC)).
CC       May thus play an important role in tumorigenesis of NSCLCs.
CC   -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
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DR   EMBL; AF176832; AAF70379.1; -; mRNA.
DR   EMBL; AF283343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF283342; AAL38107.1; -; Genomic_DNA.
DR   EMBL; AF283327; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283328; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283329; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283330; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283331; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283332; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283333; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283334; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283335; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283336; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283337; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283338; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283339; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283340; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283341; AAL38107.1; JOINED; Genomic_DNA.
DR   EMBL; AF283374; AAL38108.1; -; Genomic_DNA.
DR   EMBL; AF283344; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283345; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283346; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283347; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283348; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283349; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283350; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283351; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283352; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283353; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283354; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283355; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283356; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283357; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283358; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283359; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283360; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283361; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283362; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283363; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283364; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283366; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283367; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283368; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283369; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283370; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283371; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283372; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283373; AAL38108.1; JOINED; Genomic_DNA.
DR   EMBL; AF283408; AAL38109.1; -; Genomic_DNA.
DR   EMBL; AF283376; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283377; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283378; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283379; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283380; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283381; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283382; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283383; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283384; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283385; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283386; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283387; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283388; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283389; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283390; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283391; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283392; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283393; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283394; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283395; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283396; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283397; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283398; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283399; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283400; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283401; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283402; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283403; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283404; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283405; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283406; AAL38109.1; JOINED; Genomic_DNA.
DR   EMBL; AF283407; AAL38109.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS2182.1; -.
DR   RefSeq; NP_061027.2; NM_018557.2.
DR   SMR; Q9NZR2; -.
DR   BioGRID; 119750; 73.
DR   IntAct; Q9NZR2; 30.
DR   STRING; 9606.ENSP00000374135; -.
DR   GlyConnect; 1466; 4 N-Linked glycans (1 site).
DR   GlyCosmos; Q9NZR2; 46 sites, 4 glycans.
DR   GlyGen; Q9NZR2; 48 sites, 4 N-linked glycans (1 site), 2 O-linked glycans (2 sites).
DR   iPTMnet; Q9NZR2; -.
DR   PhosphoSitePlus; Q9NZR2; -.
DR   BioMuta; LRP1B; -.
DR   DMDM; 57015418; -.
DR   EPD; Q9NZR2; -.
DR   jPOST; Q9NZR2; -.
DR   MassIVE; Q9NZR2; -.
DR   MaxQB; Q9NZR2; -.
DR   PaxDb; 9606-ENSP00000374135; -.
DR   PeptideAtlas; Q9NZR2; -.
DR   ProteomicsDB; 83492; -.
DR   Antibodypedia; 33599; 75 antibodies from 18 providers.
DR   DNASU; 53353; -.
DR   Ensembl; ENST00000389484.8; ENSP00000374135.3; ENSG00000168702.18.
DR   GeneID; 53353; -.
DR   KEGG; hsa:53353; -.
DR   MANE-Select; ENST00000389484.8; ENSP00000374135.3; NM_018557.3; NP_061027.2.
DR   UCSC; uc002tvj.2; human.
DR   AGR; HGNC:6693; -.
DR   CTD; 53353; -.
DR   DisGeNET; 53353; -.
DR   GeneCards; LRP1B; -.
DR   HGNC; HGNC:6693; LRP1B.
DR   HPA; ENSG00000168702; Tissue enhanced (brain, thyroid gland).
DR   MalaCards; LRP1B; -.
DR   MIM; 608766; gene.
DR   neXtProt; NX_Q9NZR2; -.
DR   OpenTargets; ENSG00000168702; -.
DR   PharmGKB; PA30451; -.
DR   VEuPathDB; HostDB:ENSG00000168702; -.
DR   eggNOG; KOG1215; Eukaryota.
DR   GeneTree; ENSGT00940000157521; -.
DR   HOGENOM; CLU_000085_2_1_1; -.
DR   InParanoid; Q9NZR2; -.
DR   OMA; GRDEFHC; -.
DR   OrthoDB; 2876235at2759; -.
DR   PhylomeDB; Q9NZR2; -.
DR   TreeFam; TF315253; -.
DR   PathwayCommons; Q9NZR2; -.
DR   SignaLink; Q9NZR2; -.
DR   SIGNOR; Q9NZR2; -.
DR   BioGRID-ORCS; 53353; 24 hits in 1154 CRISPR screens.
DR   ChiTaRS; LRP1B; human.
DR   GeneWiki; LRP1B; -.
DR   GenomeRNAi; 53353; -.
DR   Pharos; Q9NZR2; Tbio.
DR   PRO; PR:Q9NZR2; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q9NZR2; Protein.
DR   Bgee; ENSG00000168702; Expressed in endothelial cell and 136 other cell types or tissues.
DR   ExpressionAtlas; Q9NZR2; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IDA:MGI.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; TAS:ProtInc.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc.
DR   CDD; cd00054; EGF_CA; 4.
DR   CDD; cd00112; LDLa; 28.
DR   Gene3D; 2.10.25.10; Laminin; 13.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 32.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR032485; LRP1-like_beta_prop.
DR   PANTHER; PTHR22722:SF5; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B; 1.
DR   PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF16472; DUF5050; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF14670; FXa_inhibition; 4.
DR   Pfam; PF00057; Ldl_recept_a; 30.
DR   Pfam; PF00058; Ldl_recept_b; 11.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 25.
DR   SMART; SM00179; EGF_CA; 6.
DR   SMART; SM00192; LDLa; 32.
DR   SMART; SM00135; LY; 37.
DR   SUPFAM; SSF57196; EGF/Laminin; 8.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR   SUPFAM; SSF57424; LDL receptor-like module; 32.
DR   SUPFAM; SSF63825; YWTD domain; 8.
DR   PROSITE; PS00010; ASX_HYDROXYL; 4.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 9.
DR   PROSITE; PS50026; EGF_3; 9.
DR   PROSITE; PS01187; EGF_CA; 3.
DR   PROSITE; PS01209; LDLRA_1; 27.
DR   PROSITE; PS50068; LDLRA_2; 32.
DR   PROSITE; PS51120; LDLRB; 37.
DR   Genevisible; Q9NZR2; HS.
PE   1: Evidence at protein level;
KW   Calcium; Disulfide bond; EGF-like domain; Endocytosis; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..4599
FT                   /note="Low-density lipoprotein receptor-related protein 1B"
FT                   /id="PRO_0000017319"
FT   TOPO_DOM        25..4444
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4445..4467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        4468..4599
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          31..70
FT                   /note="LDL-receptor class A 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          76..114
FT                   /note="LDL-receptor class A 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          116..154
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          155..194
FT                   /note="EGF-like 2; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          295..337
FT                   /note="LDL-receptor class B 1"
FT   REPEAT          338..381
FT                   /note="LDL-receptor class B 2"
FT   REPEAT          382..425
FT                   /note="LDL-receptor class B 3"
FT   DOMAIN          471..517
FT                   /note="EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          568..610
FT                   /note="LDL-receptor class B 4"
FT   REPEAT          611..656
FT                   /note="LDL-receptor class B 5"
FT   REPEAT          657..706
FT                   /note="LDL-receptor class B 6"
FT   REPEAT          707..750
FT                   /note="LDL-receptor class B 7"
FT   DOMAIN          794..834
FT                   /note="EGF-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          844..882
FT                   /note="LDL-receptor class A 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          885..923
FT                   /note="LDL-receptor class A 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          926..963
FT                   /note="LDL-receptor class A 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          966..1003
FT                   /note="LDL-receptor class A 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          1005..1043
FT                   /note="LDL-receptor class A 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          1052..1089
FT                   /note="LDL-receptor class A 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          1094..1132
FT                   /note="LDL-receptor class A 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          1135..1174
FT                   /note="LDL-receptor class A 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          1174..1213
FT                   /note="EGF-like 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1214..1253
FT                   /note="EGF-like 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          1300..1346
FT                   /note="LDL-receptor class B 8"
FT   REPEAT          1347..1389
FT                   /note="LDL-receptor class B 9"
FT   REPEAT          1390..1436
FT                   /note="LDL-receptor class B 10"
FT   REPEAT          1437..1480
FT                   /note="LDL-receptor class B 11"
FT   REPEAT          1481..1522
FT                   /note="LDL-receptor class B 12"
FT   DOMAIN          1527..1570
FT                   /note="EGF-like 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          1618..1660
FT                   /note="LDL-receptor class B 13"
FT   REPEAT          1661..1704
FT                   /note="LDL-receptor class B 14"
FT   REPEAT          1705..1744
FT                   /note="LDL-receptor class B 15"
FT   REPEAT          1745..1787
FT                   /note="LDL-receptor class B 16"
FT   DOMAIN          1834..1875
FT                   /note="EGF-like 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          1922..1964
FT                   /note="LDL-receptor class B 17"
FT   REPEAT          1965..2007
FT                   /note="LDL-receptor class B 28"
FT   REPEAT          2008..2051
FT                   /note="LDL-receptor class B 19"
FT   REPEAT          2052..2095
FT                   /note="LDL-receptor class B 20"
FT   DOMAIN          2143..2183
FT                   /note="EGF-like 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          2239..2280
FT                   /note="LDL-receptor class B 21"
FT   REPEAT          2281..2329
FT                   /note="LDL-receptor class B 22"
FT   REPEAT          2330..2374
FT                   /note="LDL-receptor class B 23"
FT   REPEAT          2375..2416
FT                   /note="LDL-receptor class B 24"
FT   REPEAT          2417..2459
FT                   /note="LDL-receptor class B 25"
FT   DOMAIN          2464..2504
FT                   /note="EGF-like 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2509..2548
FT                   /note="LDL-receptor class A 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2551..2587
FT                   /note="LDL-receptor class A 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2590..2626
FT                   /note="LDL-receptor class A 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2629..2675
FT                   /note="LDL-receptor class A 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2681..2717
FT                   /note="LDL-receptor class A 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2719..2757
FT                   /note="LDL-receptor class A 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2760..2800
FT                   /note="LDL-receptor class A 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2804..2841
FT                   /note="LDL-receptor class A 18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2844..2885
FT                   /note="LDL-receptor class A 19"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2890..2926
FT                   /note="LDL-receptor class A 20"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          2927..2967
FT                   /note="EGF-like 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          2968..3008
FT                   /note="EGF-like 12; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          3055..3098
FT                   /note="LDL-receptor class B 26"
FT   REPEAT          3099..3141
FT                   /note="LDL-receptor class B 27"
FT   REPEAT          3142..3185
FT                   /note="LDL-receptor class B 28"
FT   REPEAT          3186..3224
FT                   /note="LDL-receptor class B 29"
FT   REPEAT          3225..3268
FT                   /note="LDL-receptor class B 30"
FT   DOMAIN          3273..3314
FT                   /note="EGF-like 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          3316..3353
FT                   /note="LDL-receptor class A 21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3356..3392
FT                   /note="LDL-receptor class A 22"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3395..3432
FT                   /note="LDL-receptor class A 23"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3435..3472
FT                   /note="LDL-receptor class A 24"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3475..3511
FT                   /note="LDL-receptor class A 25"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3514..3550
FT                   /note="LDL-receptor class A 26"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3552..3588
FT                   /note="LDL-receptor class A 27"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3593..3629
FT                   /note="LDL-receptor class A 28"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3631..3668
FT                   /note="LDL-receptor class A 29"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3673..3711
FT                   /note="LDL-receptor class A 30"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3714..3752
FT                   /note="LDL-receptor class A 31"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3761..3797
FT                   /note="LDL-receptor class A 32"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DOMAIN          3801..3843
FT                   /note="EGF-like 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          3844..3881
FT                   /note="EGF-like 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REPEAT          3933..3980
FT                   /note="LDL-receptor class B 31"
FT   REPEAT          3981..4038
FT                   /note="LDL-receptor class B 32"
FT   REPEAT          4039..4082
FT                   /note="LDL-receptor class B 33"
FT   REPEAT          4083..4127
FT                   /note="LDL-receptor class B 34"
FT   DOMAIN          4171..4208
FT                   /note="EGF-like 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          4213..4249
FT                   /note="EGF-like 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          4249..4285
FT                   /note="EGF-like 18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          4285..4321
FT                   /note="EGF-like 19"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          4321..4357
FT                   /note="EGF-like 20"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          4357..4392
FT                   /note="EGF-like 21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          4390..4427
FT                   /note="EGF-like 22"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   MOTIF           4492..4495
FT                   /note="Endocytosis signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           4559..4562
FT                   /note="Endocytosis signal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        190
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        220
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        313
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        360
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        443
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        725
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        758
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        829
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        883
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        919
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1041
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1089
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1209
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1298
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1502
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1549
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1636
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1754
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1816
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1921
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1983
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2458
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2488
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2507
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2549
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2626
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2647
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2802
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2892
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3034
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3066
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3076
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3310
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3316
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3682
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3877
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3894
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3906
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4017
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4381
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4420
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        32..45
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        77..90
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        97..113
FT                   /evidence="ECO:0000250"
FT   DISULFID        120..129
FT                   /evidence="ECO:0000250"
FT   DISULFID        125..138
FT                   /evidence="ECO:0000250"
FT   DISULFID        140..153
FT                   /evidence="ECO:0000250"
FT   DISULFID        159..169
FT                   /evidence="ECO:0000250"
FT   DISULFID        165..178
FT                   /evidence="ECO:0000250"
FT   DISULFID        180..193
FT                   /evidence="ECO:0000250"
FT   DISULFID        798..809
FT                   /evidence="ECO:0000250"
FT   DISULFID        805..818
FT                   /evidence="ECO:0000250"
FT   DISULFID        820..833
FT                   /evidence="ECO:0000250"
FT   DISULFID        845..857
FT                   /evidence="ECO:0000250"
FT   DISULFID        852..870
FT                   /evidence="ECO:0000250"
FT   DISULFID        864..881
FT                   /evidence="ECO:0000250"
FT   DISULFID        886..898
FT                   /evidence="ECO:0000250"
FT   DISULFID        893..911
FT                   /evidence="ECO:0000250"
FT   DISULFID        905..922
FT                   /evidence="ECO:0000250"
FT   DISULFID        927..939
FT                   /evidence="ECO:0000250"
FT   DISULFID        934..952
FT                   /evidence="ECO:0000250"
FT   DISULFID        946..962
FT                   /evidence="ECO:0000250"
FT   DISULFID        967..980
FT                   /evidence="ECO:0000250"
FT   DISULFID        975..993
FT                   /evidence="ECO:0000250"
FT   DISULFID        987..1002
FT                   /evidence="ECO:0000250"
FT   DISULFID        1006..1018
FT                   /evidence="ECO:0000250"
FT   DISULFID        1013..1031
FT                   /evidence="ECO:0000250"
FT   DISULFID        1025..1042
FT                   /evidence="ECO:0000250"
FT   DISULFID        1053..1066
FT                   /evidence="ECO:0000250"
FT   DISULFID        1060..1079
FT                   /evidence="ECO:0000250"
FT   DISULFID        1073..1088
FT                   /evidence="ECO:0000250"
FT   DISULFID        1095..1109
FT                   /evidence="ECO:0000250"
FT   DISULFID        1103..1122
FT                   /evidence="ECO:0000250"
FT   DISULFID        1116..1131
FT                   /evidence="ECO:0000250"
FT   DISULFID        1136..1150
FT                   /evidence="ECO:0000250"
FT   DISULFID        1143..1163
FT                   /evidence="ECO:0000250"
FT   DISULFID        1157..1173
FT                   /evidence="ECO:0000250"
FT   DISULFID        1838..1849
FT                   /evidence="ECO:0000250"
FT   DISULFID        1845..1859
FT                   /evidence="ECO:0000250"
FT   DISULFID        1861..1874
FT                   /evidence="ECO:0000250"
FT   DISULFID        2147..2158
FT                   /evidence="ECO:0000250"
FT   DISULFID        2154..2168
FT                   /evidence="ECO:0000250"
FT   DISULFID        2170..2182
FT                   /evidence="ECO:0000250"
FT   DISULFID        2510..2523
FT                   /evidence="ECO:0000250"
FT   DISULFID        2518..2536
FT                   /evidence="ECO:0000250"
FT   DISULFID        2530..2547
FT                   /evidence="ECO:0000250"
FT   DISULFID        2552..2564
FT                   /evidence="ECO:0000250"
FT   DISULFID        2559..2577
FT                   /evidence="ECO:0000250"
FT   DISULFID        2571..2586
FT                   /evidence="ECO:0000250"
FT   DISULFID        2591..2603
FT                   /evidence="ECO:0000250"
FT   DISULFID        2598..2616
FT                   /evidence="ECO:0000250"
FT   DISULFID        2610..2625
FT                   /evidence="ECO:0000250"
FT   DISULFID        2630..2652
FT                   /evidence="ECO:0000250"
FT   DISULFID        2646..2665
FT                   /evidence="ECO:0000250"
FT   DISULFID        2659..2674
FT                   /evidence="ECO:0000250"
FT   DISULFID        2682..2694
FT                   /evidence="ECO:0000250"
FT   DISULFID        2689..2707
FT                   /evidence="ECO:0000250"
FT   DISULFID        2701..2716
FT                   /evidence="ECO:0000250"
FT   DISULFID        2720..2732
FT                   /evidence="ECO:0000250"
FT   DISULFID        2727..2745
FT                   /evidence="ECO:0000250"
FT   DISULFID        2739..2756
FT                   /evidence="ECO:0000250"
FT   DISULFID        2761..2774
FT                   /evidence="ECO:0000250"
FT   DISULFID        2768..2787
FT                   /evidence="ECO:0000250"
FT   DISULFID        2781..2799
FT                   /evidence="ECO:0000250"
FT   DISULFID        2805..2817
FT                   /evidence="ECO:0000250"
FT   DISULFID        2812..2830
FT                   /evidence="ECO:0000250"
FT   DISULFID        2824..2840
FT                   /evidence="ECO:0000250"
FT   DISULFID        2845..2857
FT                   /evidence="ECO:0000250"
FT   DISULFID        2852..2871
FT                   /evidence="ECO:0000250"
FT   DISULFID        2865..2884
FT                   /evidence="ECO:0000250"
FT   DISULFID        2891..2903
FT                   /evidence="ECO:0000250"
FT   DISULFID        2898..2916
FT                   /evidence="ECO:0000250"
FT   DISULFID        2910..2925
FT                   /evidence="ECO:0000250"
FT   DISULFID        2930..2942
FT                   /evidence="ECO:0000250"
FT   DISULFID        2938..2951
FT                   /evidence="ECO:0000250"
FT   DISULFID        2953..2966
FT                   /evidence="ECO:0000250"
FT   DISULFID        2972..2982
FT                   /evidence="ECO:0000250"
FT   DISULFID        2978..2991
FT                   /evidence="ECO:0000250"
FT   DISULFID        2993..3007
FT                   /evidence="ECO:0000250"
FT   DISULFID        3317..3329
FT                   /evidence="ECO:0000250"
FT   DISULFID        3324..3342
FT                   /evidence="ECO:0000250"
FT   DISULFID        3336..3352
FT                   /evidence="ECO:0000250"
FT   DISULFID        3357..3369
FT                   /evidence="ECO:0000250"
FT   DISULFID        3364..3382
FT                   /evidence="ECO:0000250"
FT   DISULFID        3376..3391
FT                   /evidence="ECO:0000250"
FT   DISULFID        3396..3409
FT                   /evidence="ECO:0000250"
FT   DISULFID        3403..3422
FT                   /evidence="ECO:0000250"
FT   DISULFID        3416..3431
FT                   /evidence="ECO:0000250"
FT   DISULFID        3436..3449
FT                   /evidence="ECO:0000250"
FT   DISULFID        3443..3462
FT                   /evidence="ECO:0000250"
FT   DISULFID        3456..3471
FT                   /evidence="ECO:0000250"
FT   DISULFID        3476..3488
FT                   /evidence="ECO:0000250"
FT   DISULFID        3483..3501
FT                   /evidence="ECO:0000250"
FT   DISULFID        3495..3510
FT                   /evidence="ECO:0000250"
FT   DISULFID        3515..3527
FT                   /evidence="ECO:0000250"
FT   DISULFID        3522..3540
FT                   /evidence="ECO:0000250"
FT   DISULFID        3534..3549
FT                   /evidence="ECO:0000250"
FT   DISULFID        3553..3565
FT                   /evidence="ECO:0000250"
FT   DISULFID        3560..3578
FT                   /evidence="ECO:0000250"
FT   DISULFID        3572..3587
FT                   /evidence="ECO:0000250"
FT   DISULFID        3594..3606
FT                   /evidence="ECO:0000250"
FT   DISULFID        3601..3619
FT                   /evidence="ECO:0000250"
FT   DISULFID        3613..3628
FT                   /evidence="ECO:0000250"
FT   DISULFID        3632..3645
FT                   /evidence="ECO:0000250"
FT   DISULFID        3639..3658
FT                   /evidence="ECO:0000250"
FT   DISULFID        3652..3667
FT                   /evidence="ECO:0000250"
FT   DISULFID        3674..3686
FT                   /evidence="ECO:0000250"
FT   DISULFID        3681..3699
FT                   /evidence="ECO:0000250"
FT   DISULFID        3693..3710
FT                   /evidence="ECO:0000250"
FT   DISULFID        3715..3729
FT                   /evidence="ECO:0000250"
FT   DISULFID        3723..3742
FT                   /evidence="ECO:0000250"
FT   DISULFID        3736..3751
FT                   /evidence="ECO:0000250"
FT   DISULFID        3762..3774
FT                   /evidence="ECO:0000250"
FT   DISULFID        3769..3787
FT                   /evidence="ECO:0000250"
FT   DISULFID        3781..3796
FT                   /evidence="ECO:0000250"
FT   DISULFID        3805..3818
FT                   /evidence="ECO:0000250"
FT   DISULFID        3812..3827
FT                   /evidence="ECO:0000250"
FT   DISULFID        3829..3842
FT                   /evidence="ECO:0000250"
FT   DISULFID        3848..3858
FT                   /evidence="ECO:0000250"
FT   DISULFID        3854..3867
FT                   /evidence="ECO:0000250"
FT   DISULFID        3869..3880
FT                   /evidence="ECO:0000250"
FT   DISULFID        4217..4227
FT                   /evidence="ECO:0000250"
FT   DISULFID        4221..4237
FT                   /evidence="ECO:0000250"
FT   DISULFID        4253..4263
FT                   /evidence="ECO:0000250"
FT   DISULFID        4257..4273
FT                   /evidence="ECO:0000250"
FT   DISULFID        4275..4284
FT                   /evidence="ECO:0000250"
FT   DISULFID        4289..4299
FT                   /evidence="ECO:0000250"
FT   DISULFID        4293..4309
FT                   /evidence="ECO:0000250"
FT   DISULFID        4311..4320
FT                   /evidence="ECO:0000250"
FT   DISULFID        4325..4335
FT                   /evidence="ECO:0000250"
FT   DISULFID        4329..4345
FT                   /evidence="ECO:0000250"
FT   DISULFID        4347..4356
FT                   /evidence="ECO:0000250"
FT   DISULFID        4394..4404
FT                   /evidence="ECO:0000250"
FT   DISULFID        4398..4415
FT                   /evidence="ECO:0000250"
FT   DISULFID        4417..4426
FT                   /evidence="ECO:0000250"
FT   VARIANT         48
FT                   /note="Q -> R (in dbSNP:rs12990449)"
FT                   /id="VAR_049759"
FT   VARIANT         3140
FT                   /note="Q -> R (in dbSNP:rs34488772)"
FT                   /id="VAR_049760"
FT   VARIANT         3157
FT                   /note="R -> C (in NSCLC cells; dbSNP:rs371536401)"
FT                   /evidence="ECO:0000269|PubMed:10766186"
FT                   /id="VAR_018328"
FT   VARIANT         3458
FT                   /note="E -> K (in dbSNP:rs1878740)"
FT                   /id="VAR_049761"
FT   VARIANT         3734
FT                   /note="Q -> K (in dbSNP:rs35546150)"
FT                   /id="VAR_049762"
FT   VARIANT         4264
FT                   /note="V -> L (in dbSNP:rs17386226)"
FT                   /id="VAR_049763"
FT   CONFLICT        516
FT                   /note="C -> Y (in Ref. 2; AAL38107)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1257
FT                   /note="P -> S (in Ref. 2; AAL38108)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1571
FT                   /note="E -> G (in Ref. 2; AAL38108)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2654..2655
FT                   /note="LP -> CQ (in Ref. 2; AAL38108)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   4599 AA;  515498 MW;  98B70555F46CAE66 CRC64;
     MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD
     DSDESLDTCP EEVEIKCPLN HIACLGTNKC VHLSQLCNGV LDCPDGYDEG VHCQELLSNC
     QQLNCQYKCT MVRNSTRCYC EDGFEITEDG RSCKDQDECA VYGTCSQTCR NTHGSYTCSC
     VEGYLMQPDN RSCKAKIEPT DRPPILLIAN FETIEVFYLN GSKMATLSSV NGNEIHTLDF
     IYNEDMICWI ESRESSNQLK CIQITKAGGL TDEWTINILQ SFHNVQQMAI DWLTRNLYFV
     DHVGDRIFVC NSNGSVCVTL IDLELHNPKA IAVDPIAGKL FFTDYGNVAK VERCDMDGMN
     RTRIIDSKTE QPAALALDLV NKLVYWVDLY LDYVGVVDYQ GKNRHTVIQG RQVRHLYGIT
     VFEDYLYATN SDNYNIVRIN RFNGTDIHSL IKIENAWGIR IYQKRTQPTV RSHACEVDPY
     GMPGGCSHIC LLSSSYKTRT CRCRTGFNLG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL
     NTKIADEYMI PIENLVNPRA LDFHAETNYI YFADTTSFLI GRQKIDGTER ETILKDDLDN
     VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGEMSHPRGI VVDPVNGWMY
     WTDWEEDEID DSVGRIEKAW MDGFNRQIFV TSKMLWPNGL TLDFHTNTLY WCDAYYDHIE
     KVFLNGTHRK IVYSGRELNH PFGLSHHGNY VFWTDYMNGS IFQLDLITSE VTLLRHERPP
     LFGLQIYDPR KQQGDNMCRV NNGGCSTLCL AIPGGRVCAC ADNQLLDENG TTCTFNPGEA
     LPHICKAGEF RCKNRHCIQA RWKCDGDDDC LDGSDEDSVN CFNHSCPDDQ FKCQNNRCIP
     KRWLCDGAND CGSNEDESNQ TCTARTCQVD QFSCGNGRCI PRAWLCDRED DCGDQTDEMA
     SCEFPTCEPL TQFVCKSGRC ISSKWHCDSD DDCGDGSDEV GCVHSCFDNQ FRCSSGRCIP
     GHWACDGDND CGDFSDEAQI NCTKEEIHSP AGCNGNEFQC HPDGNCVPDL WRCDGEKDCE
     DGSDEKGCNG TIRLCDHKTK FSCWSTGRCI NKAWVCDGDI DCEDQSDEDD CDSFLCGPPK
     HPCANDTSVC LQPEKLCNGK KDCPDGSDEG YLCDECSLNN GGCSNHCSVV PGRGIVCSCP
     EGLQLNKDNK TCEIVDYCSN HLKCSQVCEQ HKHTVKCSCY EGWKLDVDGE SCTSVDPFEA
     FIIFSIRHEI RRIDLHKRDY SLLVPGLRNT IALDFHFNQS LLYWTDVVED RIYRGKLSES
     GGVSAIEVVV EHGLATPEGL TVDWIAGNIY WIDSNLDQIE VAKLDGSLRT TLIAGAMEHP
     RAIALDPRYG ILFWTDWDAN FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFEKRIV
     WTDARSDAIY SALYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLSKANKWTG
     QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANDGKGPC SHMCLINHNR SAACACPHLM
     KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYFNFITAF TVPDIDDVTV IDFDASEERL
     YWTDIKTQTI KRAFINGTGL ETVISRDIQS IRGLAVDWVS RNLYWISSEF DETQINVARL
     DGSLKTSIIH GIDKPQCLAA HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI
     DYVENKLYWI SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL
     GTCSKRDGRN PTILRNKTSG VVHMKVYDKE AQQGSNSCQL NNGGCSQLCL PTSETTRTCM
     CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPSDKM DALMPISGTS FAVGIDFHAE
     NDTIYWTDMG FNKISRAKRD QTWKEDIITN GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA
     RLNGSFRYVI ISQGLDQPRS IAVHPEKGLL FWTEWGQMPC IGKARLDGSE KVVLVSMGIA
     WPNGISIDYE ENKLYWCDAR TDKIERIDLE TGGNREMVLS GSNVDMFSVA VFGAYIYWSD
     RAHANGSVRR GHKNDATETI TMRTGLGVNL KEVKIFNRVR EKGTNVCARD NGGCKQLCLY
     RGNSRRTCAC AHGYLAEDGV TCLRHEGYLL YSGRTILKSI HLSDETNLNS PIRPYENPRY
     FKNVIALAFD YNQRRKGTNR IFYSDAHFGN IQLIKDNWED RQVIVENVGS VEGLAYHRAW
     DTLYWTSSTT SSITRHTVDQ TRPGAFDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ
     HPSIMRSTLT GKNAQVVVST DILTPNGLTI DYRAEKLYFS DGSLGKIERC EYDGSQRHVI
     VKSGPGTFLS LAVYDNYIFW SDWGRRAILR SNKYTGGDTK ILRSDIPHQP MGIIAVANDT
     NSCELSPCAL LNGGCHDLCL LTPNGRVNCS CRGDRILLED NRCVTKNSSC NAYSEFECGN
     GECIDYQLTC DGIPHCKDKS DEKLLYCENR SCRRGFKPCY NRRCIPHGKL CDGENDCGDN
     SDELDCKVST CATVEFRCAD GTCIPRSARC NQNIDCADAS DEKNCNNTDC THFYKLGVKT
     TGFIRCNSTS LCVLPTWICD GSNDCGDYSD ELKCPVQNKH KCEENYFSCP SGRCILNTWI
     CDGQKDCEDG RDEFHCDSSC SWNQFACSAQ KCISKHWICD GEDDCGDGLD ESDSICGAIT
     CAADMFSCQG SRACVPRHWL CDGERDCPDG SDELSTAGCA PNNTCDENAF MCHNKVCIPK
     QFVCDHDDDC GDGSDESPQC GYRQCGTEEF SCADGRCLLN TQWQCDGDFD CPDHSDEAPL
     NPKCKSAEQS CNSSFFMCKN GRCIPSGGLC DNKDDCGDGS DERNCHINEC LSKKVSGCSQ
     DCQDLPVSYK CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CLCTDGYEIQ
     PDNPNGCKSL SDEEPFLILA DHHEIRKIST DGSNYTLLKQ GLNNVIAIDF DYREEFIYWI
     DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN LYWSDTEKRI IEVSKLNGLY
     PTILVSKRLK FPRDLSLDPQ AGYLYWIDCC EYPHIGRVGM DGTNQSVVIE TKISRPMALT
     IDYVNRRLYW ADENHIEFSN MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRA
     HKTSGADRLS LIYSWHAITD IQVYHSYRQP DVSKHLCMIN NGGCSHLCLL APGKTHTCAC
     PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD DCPEFRCQPG
     RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLSGQ FKCTKNQKCI PVNLRCNGQD
     DCGDEEDERD CPENSCSPDY FQCKTTKHCI SKLWVCDEDP DCADASDEAN CDKKTCGPHE
     FQCKNNNCIP DHWRCDSQND CSDNSDEENC KPQTCTLKDF LCANGDCVSS RFWCDGDFDC
     ADGSDERNCE TSCSKDQFRC SNGQCIPAKW KCDGHEDCKY GEDEKSCEPA SPTCSSREYI
     CASDGCISAS LKCNGEYDCA DGSDEMDCVT ECKEDQFRCK NKAHCIPIRW LCDGIHDCVD
     GSDEENCERG GNICRADEFL CNNSLCKLHF WVCDGEDDCG DNSDEAPDMC VKFLCPSTRP
     HRCRNNRICL QSEQMCNGID ECGDNSDEDH CGGKLTYKAR PCKKDEFACS NKKCIPMDLQ
     CDRLDDCGDG SDEQGCRIAP TEYTCEDNVN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKNR
     QCEDLNECLV FGTCSHQCIN VEGSYKCVCD QNFQERNNTC IAEGSEDQVL YIANDTDILG
     FIYPFNYSGD HQQISHIEHN SRITGMDVYY QRDMIIWSTQ FNPGGIFYKR IHGREKRQAN
     SGLICPEFKR PRDIAVDWVA GNIYWTDHSR MHWFSYYTTH WTSLRYSINV GQLNGPNCTR
     LLTNMAGEPY AIAVNPKRGM MYWTVVGDHS HIEEAAMDGT LRRILVQKNL QRPTGLAVDY
     FSERIYWADF ELSIIGSVLY DGSNSVVSVS SKQGLLHPHR IDIFEDYIYG AGPKNGVFRV
     QKFGHGSVEY LALNIDKTKG VLISHRYKQL DLPNPCLDLA CEFLCLLNPS GATCVCPEGK
     YLINGTCNDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGERCEV NHCSNYCQNG
     GTCVPSVLGR PTCSCALGFT GPNCGKTVCE DFCQNGGTCI VTAGNQPYCH CQPEYTGDRC
     QYYVCHHYCV NSESCTIGDD GSVECVCPTR YEGPKCEVDK CVRCHGGHCI INKDSEDIFC
     NCTNGKIASS CQLCDGYCYN GGTCQLDPET NVPVCLCSTN WSGTQCERPA PKSSKSDHIS
     TRSIAIIVPL VLLVTLITTL VIGLVLCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV
     DHDHNDGGLL DPGFMIDPTK ARYIGGGPSA FKLPHTAPPI YLNSDLKGPL TAGPTNYSNP
     VYAKLYMDGQ NCRNSLGSVD ERKELLPKKI EIGIRETVA
//